Artemisinin and Trioxane-Analogs
Recent publications:
"Peroxide Dyads from Natural Artemisinin and Synthetic Perorthoesters and Endoperoxides" Axel G. Griesbeck und Angela Raabe, Synlett 2009, 1514-1516.
"Antimalarial Peroxide Dyads from Natural Artemisinin and Hydroxyalkylated 1,2,4-Trioxanes" Axel G. Griesbeck, Jörg Neudörfl, Achim Hörauf, Sabine Specht und Angela Raabe, J. Med. Chem. 2009, 52, 3420-3423.
"Synthetic approaches to mono- and bicyclic perortho-esters with a central 1,2,4-trioxane ring as the privileged lead structure in antimalarial and antitumor-active peroxides and clarification of the peroxide relevance" Axel Griesbeck, Maria Bräutigam, Margarethe Kleczka und Angela Raabe, Molecules 2017, 22, 110, DOI: 10.3390/molecules22010119: http://www.mdpi.com/1420-3049/22/1/119.
"Spirofused and annulated 1,2,4-trioxepane-, trioxocane-, and trioxonane cyclohexadienones: Cyclic peroxides with unusual ring conformation dynamics" Angelika Eske, Carolina Fendinger, Bernd Goldfuss, Matthis Jonen, Jens Lefarth, Jörg.-M. Neudörfl, Matthias Spilles, and Axel G. Griesbeck, Angew. Chem. Int. Ed. 2018, 57,